Open to Debate is hosted and moderated by John Donvan, who opens each episode by framing a single debatable proposition against a current-events hook, then introduces two or more debaters arguing opposing positions. The core format is a formal, timed debate: credentials are established for each side, a moderated exchange follows, and many episodes are recorded live in front of an audience at partner venues like the Council on Foreign Relations or Johns Hopkins University's Hopkins Bloomberg Center. Guests are typically subject-matter experts, academics, authors, economists, and policy figures rather than repeat personalities — sample debaters include bioethicist Peter Singer on assisted suicide, economist Simon Johnson and Andrew Yang on AI and the future of work, and Inez Stepman and Wendy Walsh on feminism's legacy. Recurring subject areas include artificial intelligence (its investment bubble, labor-market effects, and use in warfare), bioethics and end-of-life policy, gender politics, media and entertainment economics, and political economy. The show departs from the strict debate format for occasional interview segments, including a 'Think Twice' series built around nonfiction authors and a crossover episode recorded with the podcast Smart Girl Dumb Questions. Episodes are grounded in specific citations — box office figures, survey statistics, legislative detail — rather than purely rhetorical argument. Runtimes are typically under an hour, with some live or interview episodes running longer. The show benefits listeners who want to hear opposing, credentialed viewpoints argued directly against each other rather than a single host's take. Production draws on both studio segments and live event tapings done with institutional co-sponsors.