Therapy for Black Girls is primarily a one-on-one interview show, with host Dr. Joy Harden Bradford, a licensed psychologist based in Atlanta, leading conversations with therapists, physicians, and scholars. A recurring alternate format is a panel discussion in which Harden Bradford is joined by another therapist or the show's own producers to recap episodes of television series like Insecure and Bel-Air, using character storylines (substance use, boundary-setting, interracial relationships) as case studies for mental health concepts. Other episodes move into health equity territory, covering Black maternal health, postpartum risk, and the history of medical racism, citing figures such as J. Marion Sims and Henrietta Lacks, typically alongside a physician guest. The show also brings on academic guests to discuss Black history, including scholars researching the Black Panther Party and the numerical majority of women within it who are often left out of popular accounts. Recurring guest Dr. Donna Oriowo, a sex and relationship therapist, addresses colorism, texturism, and interracial relationship dynamics. Producers Elise Ellis and Frida Lucas periodically join as panelists for the pop-culture recap episodes. Episodes run roughly 35 to 80 minutes and mix clinical explanation with narrative recap and historical framing rather than sticking to a single structure. The show is aimed at listeners seeking mental health education grounded in Black women's specific social and medical context, as well as fans of Black-led television looking for a therapist's-eye analysis. It is produced with iHeartPodcasts on a weekly release schedule. Guests and hosts speak from professional expertise and, at times, lived experience, keeping the tone conversational rather than strictly clinical.