Making Sense with Sam Harris runs two recurring formats: long single-guest interviews ranging from about 20 to 110 minutes, and shorter subscriber-oriented 'More From Sam' Q&A episodes where Harris responds to listener questions about the week's news. Interview guests are typically scientists, technologists, journalists, and philosophers; this sample includes causal-AI researcher Judea Pearl, Tristan Harris on social media and AI harms, political writer Jonathan Rauch on the language of fascism, and effective-altruism philosopher Will MacAskill. Recurring subjects across both formats include AI-driven job loss and extinction-risk scenarios, the ethics and track record of effective altruism, the condition of US democracy under Trump, and arguments against religious apologetics from a secular standpoint. The Q&A episodes also examine media and podcasting responsibility, discussing figures such as Joe Rogan, Theo Von, and Tucker Carlson in relation to conspiracy theories reaching large audiences. Harris regularly references mindfulness and meditation, tied to his Waking Up app, as a way of processing distressing news rather than as a standalone topic. Israel, antisemitism, and Middle East politics come up in both interview and Q&A episodes. The tone is analytical and often argumentative, with Harris pressing guests and explaining why he declines to debate certain public figures. Full Q&A episodes are partially paywalled, with only an initial segment released publicly before a subscription prompt. Listeners drawn to AI policy debates, philosophy of religion, or secular political commentary on the Trump era make up the core audience, spanning quick news-reaction episodes and long-form guest conversations.