Endless Thread is produced by WBUR, Boston's public radio station, and hosted by Ben Brock Johnson and Amory Sivertson, with producer Grace Tatter and others occasionally co-hosting or bringing in stories they reported themselves. Episodes typically follow a narrative-reporting format, opening with an online artifact - a Reddit thread, a TikTok account, a meme, a lawsuit tied to a viral post - and tracing how it originated, spread, and what it caused. Some episodes lean more conversational, with the co-hosts working through a story together in a panel-style exchange. Guests are usually participants in the story itself: a librarian who runs a satirical beige-aesthetic TikTok account, a Scottish folk singer targeted by AI-generated images, a reporter who investigated a DIY residential tunnel project. Recurring themes include internet aesthetics and consumer trends, AI-generated harassment and non-consensual deepfakes, and defamation or First Amendment cases that arise once online content escalates into legal action. The show periodically revisits earlier subjects through 'Rewind' episodes that update listeners on how a story developed. Episodes run roughly 20 to 30 minutes and credit producers and editors including Meg Kramer and Kalyani Saxena. The audience is people interested in internet culture and online communities who also want the story followed past the initial viral moment into its legal, social, or personal consequences. Tone varies within a single episode, moving between comic (an anonymous margarine-burying saga) and serious (non-consensual sexual imagery, harassment statistics, courtroom testimony). Sponsor segments from outlets such as MathWorks and BU Questrom's 'Is Business Broken?' appear in some episodes but are distinct from the reported content.