The Root Cause Medicine Podcast · Rupa Health

The Ageless Brain: Dr. Dale Bredesen on Preventing Cognitive Decline

June 12, 2025·1 hr 1 min·2 clips
She came in to see me when she was literally going to commit suicide - she's now walking across the United States at 80.
Neurologist Dr. Dale Bredesen discusses his pioneering work reversing Alzheimer's disease through precision medicine, explaining how cognitive decline starts decades before diagnosis and can be detected with new blood tests like P-tau 217. He shares his journey from being rejected by the medical establishment to conducting clinical trials showing clear improvement, and advocates for a 'cognoscopy' brain health screening starting at age 35-45.

As heard by us

A dense but practical look at biomarkers for catching cognitive decline early.

The episode makes a plain case for catching cognitive decline early, with Dr. Dale Bredesen arguing for biomarkers that can be acted on rather than accepted late. Dr.

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Why you'd press play

If you want a real brain-screening map, this episode walks you through the cognoscopy and the markers that fit together.

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