The Root Cause Medicine Podcast · Rupa Health

10 New Oxidative Stress & Gut Health Biomarkers to Know

·58 min·3 clips

Antibodies to lipopolysaccharides can drive metabolic endotoxemia, cardiovascular disease, and autoimmunity.

The episode begins with Dr. Kate Kresge introducing Dr. Cheryl Burdett and framing the session around 10 novel stress and oxidation markers. The conversation quickly turns clinical. Burdett explains why clinicians may want to look beyond a single symptom and screen for patterns that point to gut dysfunction, microbial translocation, and oxidative injury. Several markers are named directly. F2 isoprostanes come up as part of the oxidative picture. 8-OHDG is discussed as a marker tied to mitochondrial damage and toxic burden. Total glutathione is presented as part of the body's antioxidant capacity. Anti-zonulin antibodies, anti-LPS antibodies, and secretory IgA are folded into the broader gut and immune conversation. Kresge keeps the discussion grounded in practical use. Burdett describes how these tests can be used in people with gut issues and chronic illnesses. The show moves from mechanism to interpretation to what to do if the markers are elevated or abnormal. It also stresses that these results should be read together, not in isolation. That matters because the goal is to see whether the body is handling stressors well or has slipped into imbalance. Burdett places the markers inside a broader functional medicine framework. Rather than treating them as lab trivia, the episode asks what they reveal about oxidative stress and other underlying stressors. The tone stays measured and explanatory throughout. Kresge clarifies, Burdett expands, and the conversation keeps coming back to the patient-facing meaning of the data. The result is a dense but usable clinical walkthrough. Listeners hear how elevated oxidative markers can point toward exposures such as mold or other toxins. They also hear why a high result should lead to investigation, not just labeling. The episode is especially interested in what the biomarkers can tell a clinician who is trying to make sense of persistent symptoms. It closes the loop by returning to the promise of the tests themselves: a more simultaneous view of permeability, translocation, and oxidative damage than a narrow one-marker approach allows.

As heard by us

A focused clinical discussion of stress, oxidation, and gut markers in practice.

Dr. Kate Kresge and Dr. Cheryl Burdett keep this one grounded in the mechanics of functional medicine. They walk through 10 stress and oxidation markers, including F2 isoprostanes, 8-OHDG, total glutathione, anti-zonulin antibodies, anti-LPS antibodies, and secretory IgA, and…

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Why you'd press play

You want a cleaner way to think about gut issues and oxidative stress markers.

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