The Funk'tional Nutrition Podcast · Erin Holt

OneSkin & the Future of Skincare: How Peptides Reverse Biological Aging | Ep 374

·39 min·3 clips

Carolina discovered that top-selling anti-aging products can actually accelerate skin aging and cause inflammation.

This episode features host Erin Holt interviewing Carolina Reis-Oliveira, PhD, CEO and co-founder of the skincare company OneSkin. Holt is a functional nutritionist, and Reis-Oliveira is a scientist focused on using research to prevent age-related diseases. Their conversation centers on OneSkin's approach to skin health and its proprietary OS-01 peptide. Reis-Oliveira explains her background in stem cell biology and testing anti-aging products, where she found many caused inflammation or toxicity. She identifies senescent "zombie" cells as a key driver of skin aging, leading to collagen degradation and a compromised skin barrier. OneSkin screened over 900 peptides to find OS-01, which targets these senescent cells by activating DNA repair pathways and reducing inflammation. Lab studies showed the peptide could reduce senescent cells by up to 40% and reverse the skin's biological age by 2.5 years after just five days of treatment. Early human data indicates one year of use can reduce biological skin age by an average of 3.3 years. A surprising insight is that treating skin externally with their body lotion reduced inflammatory markers in participants' blood, suggesting skin health impacts systemic inflammation. Reis-Oliveira challenges the common overuse of actives, advising that less is more and over-exfoliation can damage the skin barrier. She notes their products are certified by the National Eczema Association and are fragrance-free. The company also developed a scalp serum targeting senescent cells in hair follicles to address hair thinning. The tone is conversational and educational, blending personal anecdote with scientific explanation. The style is promotional yet informative, as Holt is a satisfied customer sharing the product with her audience. Listeners interested in non-invasive, science-backed skincare alternatives to procedures like Botox would enjoy this episode. Those seeking a critical or independent review of skincare claims might find it less suitable.

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