Protein Production Technology Podcast · FPG Media

Episode 33: Cleaner, Leaner, Smarter: How Advanced Downstream Processes are Powering Sustainable and Functional Protein Production In Partnership with Pall Corporation

·56 min·4 clips

Antoine Charbonneau says PERFORM 4.0 has cut DOE process-development time by 50% and is used daily in the lab.

The program opens with PPTI positioning itself as a digital hub for the alternative protein sector. It stresses the full value chain, from early-stage research and process development through to commercial scale-up and market launch. The hosts also point listeners toward the Future of Protein Production Conference in Amsterdam. From there, the discussion narrows to downstream design as the point where sustainability claims meet real engineering choices. One theme is non-functional yeast protein. Because it does not rely on native rheological functionality, the separation problem becomes easier to handle. The guests explain that pH differentiation and temperature can be used to separate the biomass fraction they want. They also note that those same tools are harder to use when native protein characteristics must be preserved. Yield stays central throughout, along with making the process sustainable over the long run. The conversation then broadens to valorizing collateral streams from the same production system. Yeast extract can be recovered. Cell walls can move into animal nutrition. Upstream material can be used as biofertilizer. Those extra outputs are treated as part of the product design, not as leftovers. Another section turns to resin-based purification systems that combine pharma-style precision with food-scale practicality. The guests frame impurity removal as identifying the family of contaminants that needs to come out, not just chasing a single problem compound. That approach keeps the focus on taste, yield, and cleanup efficiency at the same time. The structure stays careful and explanatory, letting the technical material build in blocks. By the end, the episode reads as a practical map of how downstream design supports both functionality and commercialization.

As heard by us

A practical look at how downstream choices shape sustainable protein production.

This episode stays focused on downstream processing, and that focus helps. It makes a solid case for separating non-functional yeast proteins with pH or temperature in ways that protect yield and keep sustainability in view.

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Why you'd press play

Cleaner downstream choices, less guesswork, and a practical look at scaling alternative proteins.

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