The episode opens by announcing two major events: the successful end of the Artemis II mission and the start of US-Iran peace talks. Artemis II concluded after 10 days, with the Orion capsule landing in the Pacific near San Diego, California, following a problem-free takeoff from Cape Canaveral, Florida, on April 1st. The mission's spokesperson described the landing as a perfect descent. The crew included commander Ray Wiseman and made history with Christina Koch as the first woman to orbit the moon, Victor Glover as the first African-American, and Jeremy Hansen as the first non-American on a NASA lunar mission. This mission aims to propel future Artemis program goals, including lunar landings in 2028 and Earth orbit in 2027, alongside plans for a moon base. Simultaneously, the US and Iran began peace negotiations in Islamabad, mediated by Pakistan, with delegations led by US Vice President J.D. Vance and Iranian Parliament President Mohammad Baqer Khalilbaz. Iran proposed key conditions such as control of the Strait of Hormuz, release of frozen assets, and addressing regional issues including Lebanon. The episode shifts to Spanish politics, noting the upcoming Andalusia elections on May 17. PP candidate Juan Mamoreno, in a presentation in Granada, urged his 109 candidates to run a clean, positive campaign focused on proposals and illusion, criticizing the PSOE's plan to reintroduce taxation on donations. PSOE candidate María Jesús Montero, in Cádiz, announced a rescue plan for public health, including eliminating waiting lists, guaranteeing service within 48 hours by law, and improving health staff salaries to meet national averages, while accusing the current government of favoring privatization. Other news includes Juan Carlos I defending his legacy before the French National Assembly, where he received an award and expressed sadness over divergent judgments. The weather segment reports a radical change with a cold front bringing rain from west to east, dropping temperatures and bringing snow to northern and central Spain, with conditions expected to worsen on Sunday. The episode closes with host Daniel Relova signing off.