From ESC: Remote Monitoring for Atrial Fibrillation, Semaglutide and Tirzepatide in Patients With Heart Failure With Preserved Ejection Fraction, RSV Vaccine to Prevent Hospitalizations in Older Adults, and more

·38 min·3 clips

A two-week ECG patch only modestly increased atrial fibrillation detection and did not reduce stroke rates in a UK primary care trial.

The episode is a special edition summarizing cardiology research from the European Society of Cardiology Congress and the JAMA Network. Host Dr. Kirsten Bibbins-Domingo, Editor-in-Chief of JAMA, is joined by three JAMA editors as guests. They begin with atrial fibrillation research, covering the AMALFI trial which found remote ECG patch monitoring only modestly increased AF detection and did not reduce stroke. Next, a catheter ablation trial showed it may be safe to discontinue oral anticoagulation if AF does not recur post-ablation. The discussion moves to myocardial infarction, including the DANGER shock trial post-hoc analysis identifying a systolic blood pressure threshold of 82 mmHg for benefit from microaxial flow pumps in cardiogenic shock. The SWEETHEART trial found no benefit to H. pylori screening after MI for preventing GI bleeding. Complete revascularization is covered through the FIRE trial's three-year outcomes showing sustained benefit in elderly patients and the SLIM trial supporting complete revascularization in non-STEMI. An individual participant data meta-analysis compared TAVR versus SAVR for aortic stenosis, highlighting data sharing limitations. For heart failure with preserved ejection fraction, an emulation study suggested similar effectiveness for semaglutide and tirzepatide. Vaccine research includes the DAN-RSV trial hinting at cardiorespiratory benefits from RSV vaccination and the DAN-FLU-2 trial showing mixed results for high-dose influenza vaccine. A study linked clonal hematopoiesis (CHIP) to increased myocarditis risk. Trends research includes underrepresentation of women in cardiovascular trials and a survey showing only 26% of adults in 22 sub-Saharan African countries have ideal cardiovascular health. The episode closes with acknowledgments and production credits.

As heard by us

A brisk ESC roundup that ties trial design to clinical practice.

JAMA's ESC special pulls together a busy cardiology lineup, moving from remote ECG patch screening for asymptomatic atrial fibrillation to heart failure treatments, vaccination's cardiovascular effects, and a close comparison of TAVR and SAVR in aortic stenosis.

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Your cardiology reset for the ESC papers that matter before the news cycle moves on.

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