Inside Sports Nutrition · Bob Seebohar and Dina Griffin

Pro-Resolving Mediator Supplements - #213

·23 min·1 clip

PRM supplements are made from omega-3 precursors, not the unstable mediators themselves.

1. Inside Sports Nutrition episode 213 centers on pro-resolving mediator supplements, or PRMs, and their relationship to omega-3 fats. 2. Bob Sibahar and Dana Griffin host the show, and both say they are registered dietitians and board-certified specialists in sports dietetics. 3. The episode asks what PRM supplements are for, who might consider them, and how they differ from fish oil. 4. Bob says PRMs are made from omega-3 fats and help “resolve inflammation,” which he describes as a cleanup crew. 5. Dana contrasts PRMs with salmon and blueberries, saying those foods are a good start but not the same mechanism. 6. Bob names resolvins, protectins, and maresins as the PRM molecules discussed in episode 197. 7. He also says PRM supplements usually contain 17-HDHA, 18-HDHA, and fractionated marine lipids as precursors. 8. Dana says the research is still emerging, especially in human studies, and that PRMs work differently from omega-3s. 9. Bob links the topic to chronic low-grade inflammation and “inflamaging,” a term he uses for age-related inflammation. 10. He says blood-lipid disturbances, family history, fasting insulin, and inflammatory markers can all make PRMs more relevant. 11. Bob adds high-performing athletes as another group he sees using PRMs because of heavy training loads. 12. He says PRM supplementation may also be useful for arthritis, osteoarthritis, rheumatoid conditions, Hashimoto's, and PCOS. 13. Bob describes PRMs as lower-dose supplements than fish oil and says he uses them in addition to high-dose omega-3s for personal reasons tied to health history and genetics. 14. He says research points to roughly 1,000 to 2,000 milligrams a day, while also noting that he periodizes dosing by individual blood work and diet. 15. Dana asks about safety, and Bob says fish or marine oil allergy is a reason to avoid these products. 16. Bob says he has not read or heard of side effects and notes that PRMs do not raise the same blood-thinning concern he associates with high-dose fish oil. 17. The hosts also discuss timing, with Bob suggesting morning and evening dosing when multiple capsules are used. 18. Bob says he has taken PRMs for about three to four months and wants to see future blood work from early 2026. 19. The conversation is practical, conversational, and highly applied, with both hosts using direct examples from their own supplement routines. 20. Listeners who want supplement specifics, biomarker testing, and sports nutrition applications will get the most from this episode, while people wanting only broad nutrition basics may skip it.

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