From Our Neurons to Yours · Wu Tsai Neurosciences Institute at Stanford University, Nicholas Weiler

Is Alzheimer's an energy crisis in the brain? Inflammation, metabolism and a new path in the search for cures | Kati Andreasson

·43 min·3 clips
Kati Andreasen explains how NSAIDs cut Alzheimer's risk by 25%, launching her two-decade quest into inflammation.
Host Nicholas Weiler interviews Stanford physician-scientist Kati Andreasen about her research challenging the amyloid hypothesis in Alzheimer's disease. Andreasen explores how inflammation and energy metabolism in brain immune cells like microglia and astrocytes drive the disease, with findings that targeting peripheral immune pathways or repurposing cancer drugs could offer new treatments.

As heard by us

A sharp look at why clearing plaques has not been enough.

This episode moves past the usual amyloid-only framing and asks whether inflammation belongs in the Alzheimer story too. Kati Andreasen, drawing on two decades in the amyloid field, gives the discussion a grounded, unsentimental tone.

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Why you'd press play

You want a clearer map of Alzheimer's research beyond amyloid.

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